LRP1 Functions as an Atheroprotective Integrator of TGFb and PDFG Signals in the Vascular Wall: Implications for Marfan Syndrome
نویسندگان
چکیده
1 Institut Gilbert-Laustriat, UMR 7175 LC-1, Department of Pharmacology; Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Medicale/Université Louis Pasteur, Illkirch, France, 2 Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 3 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/ Institut National de la Santé et de la Recherche Medicale/Université Louis Pasteur, Illkirch, France, 4 Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
منابع مشابه
LRP1 Functions as an Atheroprotective Integrator of TGFβ and PDGF Signals in the Vascular Wall: Implications for Marfan Syndrome
BACKGROUND The multifunctional receptor LRP1 controls expression, activity and trafficking of the PDGF receptor-beta in vascular smooth muscle cells (VSMC). LRP1 is also a receptor for TGFbeta1 and is required for TGFbeta mediated inhibition of cell proliferation. METHODS AND PRINCIPAL FINDINGS We show that loss of LRP1 in VSMC (smLRP(-)) in vivo results in a Marfan-like syndrome with nuclear...
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LDL receptor-related protein 1 (LRP1) is highly expressed in the vascular wall and is mainly associated with macrophages and vascular smooth muscle cells (VSMCs). Overexpression of LRP1 in atherosclerotic lesions has been demonstrated in several animal models and human lesions. Clinical studies have suggested a relation between alterations in LRP1 expression and coronary heart disease. Indeed, ...
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